Sculptra vs Rejuran: which problem are you treating?

The FDA describes Sculptra as a dermal filler, but it works differently from a hyaluronic acid gel filler. PLLA relies on a controlled foreign-body response: the particles prompt fibroblasts to make collagen, which builds new volume over time ^[1]. That is why results come gradually across a course.

Polynucleotides are proposed to form a water-loving, scaffold-like matrix that supports tissue repair and hydration ^[2], and their longer DNA chains are linked to extracellular matrix support ^[3]. The aim is better skin quality, not shape.

Sculptra has the larger trial. In a randomised study of adults with moderate or severe cheek wrinkles, the treated group received up to one 150 mg vial per cheek at each session, with up to three more sessions a month apart. Response rates against untreated controls were 66.2% vs 38.6% at month 7, 70.6% vs 31.1% at month 9 and 71.6% vs 26.1% at month 12 ^[4]. The first efficacy assessment came at month 7, after the treatment course; because the effect builds gradually over that course, Sculptra suits people who are not working to a near deadline.

Rejuran’s trials are smaller and measure skin quality. In a split-face trial of 27 adults, the polynucleotide side showed higher improvement rates for elasticity, hydration, roughness and pore volume than non-cross-linked hyaluronic acid, with similar overall scores ^[5]. In a 30-person crow’s feet trial, 41.38% of Rejuran-treated sides improved at 12 weeks ^[6].

With Sculptra, papules and nodules are the problem most often discussed, and they have been tied to how the product is reconstituted, spread in the suspension and injected, including injection that is too superficial ^[1]. A systematic review counted two confirmed reports of visual loss after PLLA, from injections near the eyes and nose and at the temple ^[7].

With Rejuran, the common effects are short-term bumps and redness at the injection points ^[8]. A 2026 expert review found no published cases of granuloma or vascular occlusion with polynucleotides to date, while stressing that the evidence base is still limited ^[2].

Many faces have more than one of these concerns at once. A useful consultation starts with the change that matters most to you, then works back to the product.

Combining them is a clinical judgement rather than a tested protocol. A Korean survey describes polynucleotides used alongside fillers, toxins and energy-based devices for scars ^[9], but we found no study testing a Sculptra and Rejuran plan, so any combination needs an assessment of your skin and the two products.

Delight Dermatology Clinic in Seoul lists Rejuran Healer at KRW 300,000–500,000 per 2 cc session and a 5 cc Rejuran booster at KRW 550,000–800,000. Sculptra is not on its price list; its collagen stimulator is Juvelook Volume, a PDLLA and hyaluronic acid product listed at KRW 500,000–700,000 per vial. Prices checked 2026-10-18; confirm at consultation. Compare the Juvelook page if you are weighing a collagen stimulator. For Rejuran, the total depends on the amount used per session and the number of sessions; for Juvelook Volume, count the vials across the course; Sculptra needs a separate quote.